Absolute Oral Bioavailability of Glasdegib (PF‐04449913), a Smoothened Inhibitor, in Randomized Healthy Volunteers

Glasdegib (PF‐04449913) is an oral small‐molecule inhibitor of the Hedgehog signaling pathway under development for treating myeloid malignancies. This was an open‐label phase 1, randomized, 2‐sequence, 2‐treatment, 2‐period, crossover study evaluating the absolute bioavailability of glasdegib in he...

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Detalles Bibliográficos
Autores principales: Shaik, Naveed, Hee, Brian, Liang, Yali, LaBadie, Robert Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850403/
https://www.ncbi.nlm.nih.gov/pubmed/30977980
http://dx.doi.org/10.1002/cpdd.692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850403/
https://www.ncbi.nlm.nih.gov/pubmed/30977980
http://dx.doi.org/10.1002/cpdd.692

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