Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster

Dysfunctional mitochondria have been implicated in aging and age-related disorders such as Parkinson’s diseases (PD). We previously showed that pink1 and parkin, two familial PD genes, function in a linear pathway to maintain mitochondrial integrity and function. Studies of mammalian cell lines also...

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Detalles Bibliográficos
Autores principales: Si, Hongbin, Ma, Peng, Liang, Qiying, Yin, Youjie, Wang, Ping, Zhang, Qi, Wang, Saifei, Deng, Hansong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850535/
https://www.ncbi.nlm.nih.gov/pubmed/31714929
http://dx.doi.org/10.1371/journal.pone.0225214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850535/
https://www.ncbi.nlm.nih.gov/pubmed/31714929
http://dx.doi.org/10.1371/journal.pone.0225214

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