Pharmacologic effects of naldemedine, a peripherally acting μ‐opioid receptor antagonist, in in vitro and in vivo models of opioid‐induced constipation

BACKGROUND: Naldemedine (S‐297995) is a peripherally acting μ‐opioid receptor antagonist developed as a once‐daily oral drug for opioid‐induced constipation (OIC) in adults with chronic noncancer or cancer pain. This study characterized the pharmacological effects of naldemedine in vitro and in vivo...

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Detalles Bibliográficos
Autores principales: Kanemasa, Toshiyuki, Koike, Katsumi, Arai, Tohko, Ono, Hiroko, Horita, Narumi, Chiba, Hiroki, Nakamura, Atsushi, Morioka, Yasuhide, Kihara, Tsuyoshi, Hasegawa, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850587/
https://www.ncbi.nlm.nih.gov/pubmed/30821019
http://dx.doi.org/10.1111/nmo.13563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850587/
https://www.ncbi.nlm.nih.gov/pubmed/30821019
http://dx.doi.org/10.1111/nmo.13563

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