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Drug repurposing for Dravet syndrome in scn1Lab (−/−) mutant zebrafish

Dravet syndrome (DS) is a severe genetic epileptic encephalopathy with onset during the first year of life. Zebrafish models recapitulating human diseases are often used as drug discovery platforms, but also for drug repurposing testing. It was recently shown that pharmacological modulation of three...

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Detalles Bibliográficos
Autores principales: Sourbron, Jo, Partoens, Michèle, Scheldeman, Chloë, Zhang, Yifan, Lagae, Lieven, de Witte, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850687/
https://www.ncbi.nlm.nih.gov/pubmed/30663052
http://dx.doi.org/10.1111/epi.14647