Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016). But how is cholesterol, an abundant lipid, regulated tightly enough to control a signaling system that can cause birth de...

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Detalles Bibliográficos
Autores principales: Kinnebrew, Maia, Iverson, Ellen J, Patel, Bhaven B, Pusapati, Ganesh V, Kong, Jennifer H, Johnson, Kristen A, Luchetti, Giovanni, Eckert, Kaitlyn M, McDonald, Jeffrey G, Covey, Douglas F, Siebold, Christian, Radhakrishnan, Arun, Rohatgi, Rajat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850779/
https://www.ncbi.nlm.nih.gov/pubmed/31657721
http://dx.doi.org/10.7554/eLife.50051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850779/
https://www.ncbi.nlm.nih.gov/pubmed/31657721
http://dx.doi.org/10.7554/eLife.50051

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