PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors. An siRNA screen of all human protein phosphatases revealed that a poorly studied protein phosphatase, PPM1H, count...

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Detalles Bibliográficos
Autores principales: Berndsen, Kerryn, Lis, Pawel, Yeshaw, Wondwossen M, Wawro, Paulina S, Nirujogi, Raja S, Wightman, Melanie, Macartney, Thomas, Dorward, Mark, Knebel, Axel, Tonelli, Francesca, Pfeffer, Suzanne R, Alessi, Dario R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850886/
https://www.ncbi.nlm.nih.gov/pubmed/31663853
http://dx.doi.org/10.7554/eLife.50416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850886/
https://www.ncbi.nlm.nih.gov/pubmed/31663853
http://dx.doi.org/10.7554/eLife.50416

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