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Down‐regulation of GAS5 ameliorates myocardial ischaemia/reperfusion injury via the miR‐335/ROCK1/AKT/GSK‐3β axis

Growth arrest‐specific transcript 5 (GAS5), along non‐coding RNA (LncRNA), is highly expressed in hypoxia/reoxygenation (H/R)‐cardiomyocytes and promotes H/R‐induced apoptosis. In this study, we determined whether down‐regulation of GAS5 ameliorates myocardial ischaemia/reperfusion (I/R) injury and...

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Detalles Bibliográficos
Autores principales: Wu, Nan, Zhang, Xiaowen, Bao, Yandong, Yu, Hang, Jia, Dalin, Ma, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850918/
https://www.ncbi.nlm.nih.gov/pubmed/31625671
http://dx.doi.org/10.1111/jcmm.14724