SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress

Suppressor of morphogenesis in genitalia 1 (SMG1) and ataxia telangiectasia mutated (ATM) are members of the PI3‐kinase like–kinase (PIKK) family of proteins. ATM is a well‐established tumour suppressor. Loss of one or both alleles of ATM results in an increased risk of cancer development, particula...

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Detalles Bibliográficos
Autores principales: Ho, Uda, Luff, John, James, Alexander, Lee, Cheok Soon, Quek, Hazel, Lai, Hui‐Chi, Apte, Simon, Lim, Yi Chieh, Lavin, Martin F., Roberts, Tara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850945/
https://www.ncbi.nlm.nih.gov/pubmed/31565865
http://dx.doi.org/10.1111/jcmm.14685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850945/
https://www.ncbi.nlm.nih.gov/pubmed/31565865
http://dx.doi.org/10.1111/jcmm.14685

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