Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau

Scientific evidence suggests that α-synuclein and tau have prion-like properties and that prion-like spreading and seeding of misfolded protein aggregates constitutes a central mechanism for neurodegeneration. Heparan sulfate proteoglycans (HSPGs) in the plasma membrane support this process by attac...

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Detalles Bibliográficos
Autores principales: Hudák, Anett, Kusz, Erzsébet, Domonkos, Ildikó, Jósvay, Katalin, Kodamullil, Alpha Tom, Szilák, László, Hofmann-Apitius, Martin, Letoha, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851098/
https://www.ncbi.nlm.nih.gov/pubmed/31719623
http://dx.doi.org/10.1038/s41598-019-53038-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851098/
https://www.ncbi.nlm.nih.gov/pubmed/31719623
http://dx.doi.org/10.1038/s41598-019-53038-z

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