Integrative analysis of clinical and bioinformatics databases to identify anticancer properties of digoxin

Cardiac glycosides, such as digoxin, inhibit Na(+)/K(+)-ATPases and cause secondary activation of Na(+)/Ca(2+) exchangers. Preclinical investigations have suggested that digoxin may have anticancer properties. In order to clarify the functional mechanisms of digoxin in cancer, we performed an integr...

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Detalles Bibliográficos
Autores principales: Yokoyama, Satoshi, Sugimoto, Yasuhiro, Nakagawa, Chihiro, Hosomi, Kouichi, Takada, Mitsutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851125/
https://www.ncbi.nlm.nih.gov/pubmed/31719612
http://dx.doi.org/10.1038/s41598-019-53392-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851125/
https://www.ncbi.nlm.nih.gov/pubmed/31719612
http://dx.doi.org/10.1038/s41598-019-53392-y

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