Antibody cross-reactivity accounts for widespread appearance of m(1)A in 5’UTRs

N(1)-methyladenosine (m(1)A) was proposed to be a highly prevalent modification in mRNA 5’UTRs based on mapping studies using an m(1)A-binding antibody. We developed a bioinformatic approach to discover m(1)A and other modifications in mRNA throughout the transcriptome by analyzing preexisting ultra...

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Detalles Bibliográficos
Autores principales: Grozhik, Anya V., Olarerin-George, Anthony O., Sindelar, Miriam, Li, Xing, Gross, Steven S., Jaffrey, Samie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851129/
https://www.ncbi.nlm.nih.gov/pubmed/31719534
http://dx.doi.org/10.1038/s41467-019-13146-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851129/
https://www.ncbi.nlm.nih.gov/pubmed/31719534
http://dx.doi.org/10.1038/s41467-019-13146-w

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