Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness

Polycystin-1 (PC-1) and 2 (PC-2) are the products of the PKD1 and PKD2 genes, which are mutated in Autosomal Dominant Polycystic Kidney Disease (ADPKD). They form a receptor/channel complex that has been suggested to function as a mechanosensor, possibly activated by ciliary bending in the renal tub...

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Detalles Bibliográficos
Autores principales: Nigro, Elisa Agnese, Distefano, Gianfranco, Chiaravalli, Marco, Matafora, Vittoria, Castelli, Maddalena, Pesenti Gritti, Angela, Bachi, Angela, Boletta, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851149/
https://www.ncbi.nlm.nih.gov/pubmed/31719603
http://dx.doi.org/10.1038/s41598-019-53061-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851149/
https://www.ncbi.nlm.nih.gov/pubmed/31719603
http://dx.doi.org/10.1038/s41598-019-53061-0

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