Computational design and characterization of nanobody-derived peptides that stabilize the active conformation of the β(2)-adrenergic receptor (β(2)-AR)

This study aimed to design and functionally characterize peptide mimetics of the nanobody (Nb) related to the β(2)-adrenergic receptor (β(2)-AR) (nanobody-derived peptide, NDP). We postulated that the computationally derived and optimized complementarity-determining region 3 (CDR3) of Nb is sufficie...

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Detalles Bibliográficos
Autores principales: Sencanski, Milan, Glisic, Sanja, Šnajder, Marko, Veljkovic, Nevena, Poklar Ulrih, Nataša, Mavri, Janez, Vrecl, Milka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851183/
https://www.ncbi.nlm.nih.gov/pubmed/31719570
http://dx.doi.org/10.1038/s41598-019-52934-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851183/
https://www.ncbi.nlm.nih.gov/pubmed/31719570
http://dx.doi.org/10.1038/s41598-019-52934-8

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