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A split-GFP tool reveals differences in the sub-mitochondrial distribution of wt and mutant alpha-synuclein

Parkinson’s disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuronal loss that initiates in the substantia nigra pars compacta and by the formation of intracellular inclusions mainly constituted by aberrant α-synuclein (α-syn) deposits known as Lewy...

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Detalles Bibliográficos
Autores principales: Vicario, Mattia, Cieri, Domenico, Vallese, Francesca, Catoni, Cristina, Barazzuol, Lucia, Berto, Paola, Grinzato, Alessandro, Barbieri, Laura, Brini, Marisa, Calì, Tito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851186/
https://www.ncbi.nlm.nih.gov/pubmed/31719530
http://dx.doi.org/10.1038/s41419-019-2092-1