Design and development of stapled transmembrane peptides that disrupt the activity of G-protein–coupled receptor oligomers

Membrane proteins can associate into larger complexes. Examples include receptor tyrosine complexes, ion channels, transporters, and G protein–coupled receptors (GPCRs). For the latter, there is abundant evidence indicating that GPCRs assemble into complexes, through both homo- and heterodimerizatio...

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Detalles Bibliográficos
Autores principales: Botta, Joaquín, Bibic, Lucka, Killoran, Patrick, McCormick, Peter J., Howell, Lesley A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Membrane Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851324/
https://www.ncbi.nlm.nih.gov/pubmed/31467080
http://dx.doi.org/10.1074/jbc.RA119.009160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851324/
https://www.ncbi.nlm.nih.gov/pubmed/31467080
http://dx.doi.org/10.1074/jbc.RA119.009160

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