ASIC1a activation induces calcium-dependent apoptosis of BMSCs under conditions that mimic the acidic microenvironment of the degenerated intervertebral disc

Purpose: In the degenerated intervertebral disc (IVD), matrix acidity challenges transplanted bone marrow mesenchymal stem cells (BMSCs). The Ca(2+)-permeable acid-sensing ion channel 1a (ASIC1a) is responsible for acidosis-mediated tissue injury. The aim of our study was to confirm whether ASIC1a a...

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Detalles Bibliográficos
Autores principales: Cai, Feng, Hong, Xin, Tang, Xiang, Liu, Nai-Cheng, Wang, Feng, Zhu, Lei, Xie, Xin-Hui, Xie, Zhi-Yang, Wu, Xiao-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Molecular Bases of Health & Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851507/
https://www.ncbi.nlm.nih.gov/pubmed/31696219
http://dx.doi.org/10.1042/BSR20192708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851507/
https://www.ncbi.nlm.nih.gov/pubmed/31696219
http://dx.doi.org/10.1042/BSR20192708

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