Cargando…

Silencing of SPARC represses heterotopic ossification via inhibition of the MAPK signaling pathway

Heterotopic ossification (HO), the pathologic formation of extraskeletal bone, can be disabling and lethal. However, the underlying molecular mechanisms were largely unknown. The present study aimed to clarify the involvement of secreted protein acidic and rich in cysteine (SPARC) and the underlying...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Qianjun, Yang, Qianqian, Zhang, Ali, Kang, Zhiqiang, Wang, Yingsheng, Zhang, Zhentao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2019
Materias:	Gene Expression & Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851515/ https://www.ncbi.nlm.nih.gov/pubmed/31548362 http://dx.doi.org/10.1042/BSR20191805

Ejemplares similares

Full-length NF-κB repressing factor contains an XRN2 binding domain
por: Alexandrova, Jana, et al.
Publicado: (2020)

The SPARC complex defines RNAPII promoters in Trypanosoma brucei
por: Staneva, Desislava P, et al.
Publicado: (2022)

Bioinformatics method combined with logistic regression analysis reveal potentially important miRNAs in ischemic stroke
por: Wei, Zhiqiang, et al.
Publicado: (2020)

Knockdown of LINC01694 inhibits growth of gallbladder cancer cells via miR-340-5p/Sox4
por: Liu, Lei, et al.
Publicado: (2020)

Decoction of heat-clearing, detoxifying and blood stasis removing relieves acute soft tissue injury via modulating miR-26b-5p/COX2 axis to inhibit inflammation
por: Jiang, Shunwan, et al.
Publicado: (2020)

Heterochromatic Gene Silencing by Activator Interference and a Transcription Elongation Barrier
por: Johnson, Aaron, et al.
Publicado: (2013)

microRNA-27b inhibits cell proliferation and invasion in bladder cancer by targeting engrailed-2
por: Li, Yunfei, et al.
Publicado: (2021)

Integrated analysis of DNA methylation and gene expression profiles identified S100A9 as a potential biomarker in ulcerative colitis
por: Su, Shasha, et al.
Publicado: (2020)

The transcription factor Vezf1 represses the expression of the antiangiogenic factor Cited2 in endothelial cells
por: AlAbdi, Lama, et al.
Publicado: (2018)

Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1
por: Gao, Min, et al.
Publicado: (2021)

Galectin-1 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells through the inactivation of PI3K/Akt signaling pathway
por: Pang, Xinfeng, et al.
Publicado: (2020)

Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex
por: Hudson, Gregg M., et al.
Publicado: (2015)

Physical Interaction between MYCN Oncogene and Polycomb Repressive Complex 2 (PRC2) in Neuroblastoma: FUNCTIONAL AND THERAPEUTIC IMPLICATIONS
por: Corvetta, Daisy, et al.
Publicado: (2013)

Waardenburg syndrome type II in a Chinese pedigree caused by frameshift mutation in the SOX10 gene
por: Li, Li, et al.
Publicado: (2021)

The Transcription Factor Erg Controls Endothelial Cell Quiescence by Repressing Activity of Nuclear Factor (NF)-κB p65
por: Dryden, Nicola H., et al.
Publicado: (2012)

Proline Isomerase Pin1 Represses Terminal Differentiation and Myocyte Enhancer Factor 2C Function in Skeletal Muscle Cells
por: Magli, Alessandro, et al.
Publicado: (2010)

The diagnostic and prognostic values of microRNA-196a in cancer
por: Xiong, Mengqiu, et al.
Publicado: (2021)

Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1
por: Long, Jianyin, et al.
Publicado: (2020)

Associations between PHACTR1 gene polymorphisms and pulse pressure in Chinese Han population
por: Gu, Kunfang, et al.
Publicado: (2020)

The RNA-binding Protein TDP-43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-induced Silencing Complex
por: King, Isabelle N., et al.
Publicado: (2014)

Identification prognosis-associated immune genes in colon adenocarcinoma
por: Miao, Yandong, et al.
Publicado: (2020)

Detailed Structural-Functional Analysis of the Krüppel-like Factor 16 (KLF16) Transcription Factor Reveals Novel Mechanisms for Silencing Sp/KLF Sites Involved in Metabolism and Endocrinology
por: Daftary, Gaurang S., et al.
Publicado: (2012)

Identification of biomarkers associated with synovitis in rheumatoid arthritis by bioinformatics analyses
por: Li, Zhaoyan, et al.
Publicado: (2020)

Genome-wide identification and characterization of perirenal adipose tissue microRNAs in rabbits fed a high-fat diet
por: Wang, Jie, et al.
Publicado: (2021)

Weighted gene co-expression network analysis reveals specific modules and hub genes related to neuropathic pain in dorsal root ganglions
por: Cheng, Nan, et al.
Publicado: (2019)

Multiomics characteristics and immunotherapeutic potential of EZH2 in pan-cancer
por: Luo, Lianghua, et al.
Publicado: (2023)

The relationship between miRNA-210 and SCN1B in fetal rats with hypoxic-ischemic brain injury
por: Al-Ward, Hisham, et al.
Publicado: (2023)

Specificity Protein 1 (Sp1)-dependent Activation of the Synapsin I Gene (SYN1) Is Modulated by RE1-silencing Transcription Factor (REST) and 5′-Cytosine-Phosphoguanine (CpG) Methylation
por: Paonessa, Francesco, et al.
Publicado: (2013)

RORα phosphorylation by casein kinase 1α as glucose signal to regulate estrogen sulfation in human liver cells
por: Hu, Hao, et al.
Publicado: (2020)

Screening of key genes related to the prognosis of mouse sepsis
por: Chen, Muhu, et al.
Publicado: (2020)

Detection of genes responsible for cetuximab sensitization in colorectal cancer cells using CRISPR-Cas9
por: Hu, Ting-ting, et al.
Publicado: (2020)

Activation by NarL at the Escherichia coli ogt promoter
por: Ruanto, Patcharawarin, et al.
Publicado: (2020)

VCAM-1-targeted and PPARδ-agonist-loaded nanomicelles enhanced suppressing effects on apoptosis and migration of oxidized low-density lipoprotein-induced vascular smooth muscle cells
por: Wei, Gang, et al.
Publicado: (2020)

Commentary on: The potency of lncRNA MALAT1/miR-155 in altering asthmatic Th1/Th2 balance by modulation of CTLA4
por: Foronjy, Robert
Publicado: (2020)

Plasma microRNA expression levels in HIV-1-positive patients receiving antiretroviral therapy
por: Marquez-Pedroza, Jazmin, et al.
Publicado: (2020)

MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells
por: Chen, Yi-Huan, et al.
Publicado: (2020)

Effect of lentivirus-mediated CFTR overexpression on oxidative stress injury and inflammatory response in the lung tissue of COPD mouse model
por: Xu, Xiaoli, et al.
Publicado: (2020)

Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish
por: Idigo, Nwamaka J., et al.
Publicado: (2020)

Nascent SecM chain interacts with outer ribosomal surface to stabilize translation arrest
por: Muta, Mikihisa, et al.
Publicado: (2020)

The effect of different concentrations of gold nanoparticles on growth performance, toxicopathological and immunological parameters of broiler chickens
por: Hassanen, Eman I., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ufp9c4ndddv70dpjj5ilmf2jlm