Prediction of the Impact of Cytochrome P450 2C9 Genotypes on the Drug–Drug Interaction Potential of Siponimod With Physiologically‐Based Pharmacokinetic Modeling: A Comprehensive Approach for Drug Label Recommendations

We predicted the drug–drug interaction (DDI) potential of siponimod in presence of cytochrome P450 (CYP)2C9/CYP3A4 inhibitors/inducers in subjects with different CYP2C9 genotypes by physiologically‐based pharmacokinetic (PK) modeling. The model was established using in vitro and clinical PK data and...

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Detalles Bibliográficos
Autores principales: Huth, Felix, Gardin, Anne, Umehara, Kenichi, He, Handan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851657/
https://www.ncbi.nlm.nih.gov/pubmed/31199498
http://dx.doi.org/10.1002/cpt.1547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851657/
https://www.ncbi.nlm.nih.gov/pubmed/31199498
http://dx.doi.org/10.1002/cpt.1547

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