A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon Binding

The development of a fluorescent LCK inhibitor that exhibits favourable solvatochromic properties upon binding the kinase is described. Fluorescent properties were realised through the inclusion of a prodan‐derived fluorophore into the pharmacophore of an ATP‐competitive kinase inhibitor. Fluorescen...

Descripción completa

Detalles Bibliográficos
Autores principales: Fleming, Cassandra L., Sandoz, Patrick A., Inghardt, Tord, Önfelt, Björn, Grøtli, Morten, Andréasson, Joakim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851755/
https://www.ncbi.nlm.nih.gov/pubmed/31411364
http://dx.doi.org/10.1002/anie.201909536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851755/
https://www.ncbi.nlm.nih.gov/pubmed/31411364
http://dx.doi.org/10.1002/anie.201909536

Ejemplares similares