Cargando…
A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon Binding
The development of a fluorescent LCK inhibitor that exhibits favourable solvatochromic properties upon binding the kinase is described. Fluorescent properties were realised through the inclusion of a prodan‐derived fluorophore into the pharmacophore of an ATP‐competitive kinase inhibitor. Fluorescen...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851755/ https://www.ncbi.nlm.nih.gov/pubmed/31411364 http://dx.doi.org/10.1002/anie.201909536 |