TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells

Upon activation by antigen, B cells form germinal centres where they clonally expand and introduce affinity‐enhancing mutations into their B‐cell receptor genes. Somatic mutagenesis and class switch recombination (CSR) in germinal centre B cells are initiated by the activation‐induced cytidine deami...

Descripción completa

Detalles Bibliográficos
Autores principales: Schoeler, Katia, Aufschnaiter, Andreas, Messner, Simon, Derudder, Emmanuel, Herzog, Sebastian, Villunger, Andreas, Rajewsky, Klaus, Labi, Verena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Editor's Choice
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851767/
https://www.ncbi.nlm.nih.gov/pubmed/31120187
http://dx.doi.org/10.1111/febs.14934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851767/
https://www.ncbi.nlm.nih.gov/pubmed/31120187
http://dx.doi.org/10.1111/febs.14934

Ejemplares similares