Drug‐Drug Interaction Study to Assess the Effect of Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of the Novel Cereblon Modulator Avadomide (CC‐122) in Healthy Adult Subjects

Avadomide (CC‐122) is a novel immunomodulatory drug that binds to cereblon, a member of the Cullin 4‐RING E3 ubiquitin ligase complex. Avadomide has multiple pharmacologic activities including potent immune modulation, antiangiogenic, antitumor, and antiproliferative activity and is being evaluated...

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Detalles Bibliográficos
Autores principales: Ogasawara, Ken, MacGorman, Kimberly, Liu, Liangang, Chen, Jian, Carayannopoulos, Leonidas N., Zhou, Simon, Palmisano, Maria, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Drug Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851786/
https://www.ncbi.nlm.nih.gov/pubmed/31172535
http://dx.doi.org/10.1002/jcph.1453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851786/
https://www.ncbi.nlm.nih.gov/pubmed/31172535
http://dx.doi.org/10.1002/jcph.1453

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