Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide‐based substrates and covalent inhibitors

Malarial dipeptidyl aminopeptidases (DPAPs) are cysteine proteases important for parasite development thus making them attractive drug targets. In order to develop inhibitors specific to the parasite enzymes, it is necessary to map the determinants of substrate specificity of the parasite enzymes an...

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Detalles Bibliográficos
Autores principales: de Vries, Laura E., Sanchez, Mateo I., Groborz, Katarzyna, Kuppens, Laurie, Poreba, Marcin, Lehmann, Christine, Nevins, Neysa, Withers‐Martinez, Chrislaine, Hirst, David J., Yuan, Fang, Arastu‐Kapur, Shirin, Horn, Martin, Mares, Michael, Bogyo, Matthew, Drag, Marcin, Deu, Edgar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851853/
https://www.ncbi.nlm.nih.gov/pubmed/31177613
http://dx.doi.org/10.1111/febs.14953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851853/
https://www.ncbi.nlm.nih.gov/pubmed/31177613
http://dx.doi.org/10.1111/febs.14953

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