Creation of RANKL mutants with low affinity for decoy receptor OPG and their potential anti‐fibrosis activity

Fibrosis is characterized by the progressive alteration of the tissue structure due to the excessive production of extracellular matrix (ECM). The signaling system encompassing Receptor Activator of Nuclear factor NF‐κB Ligand (RANKL)/RANK/Osteoprotegerin (OPG) was discovered to play an important ro...

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Detalles Bibliográficos
Autores principales: Wang, Yizhou, Michiels, Timo, Setroikromo, Rita, van Merkerk, Ronald, Cool, Robbert H., Quax, Wim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852375/
https://www.ncbi.nlm.nih.gov/pubmed/31081236
http://dx.doi.org/10.1111/febs.14925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852375/
https://www.ncbi.nlm.nih.gov/pubmed/31081236
http://dx.doi.org/10.1111/febs.14925

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