C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

BACKGROUND: Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brain barrier the trigeminal system has been suggested a possible site of action be...

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Detalles Bibliográficos
Autores principales: Edvinsson, Jacob C. A., Warfvinge, Karin, Krause, Diana N., Blixt, Frank W., Sheykhzade, Majid, Edvinsson, Lars, Haanes, Kristian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852900/
https://www.ncbi.nlm.nih.gov/pubmed/31718551
http://dx.doi.org/10.1186/s10194-019-1055-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852900/
https://www.ncbi.nlm.nih.gov/pubmed/31718551
http://dx.doi.org/10.1186/s10194-019-1055-3

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