Cargando…

C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

BACKGROUND: Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brain barrier the trigeminal system has been suggested a possible site of action be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Edvinsson, Jacob C. A., Warfvinge, Karin, Krause, Diana N., Blixt, Frank W., Sheykhzade, Majid, Edvinsson, Lars, Haanes, Kristian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Milan 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852900/ https://www.ncbi.nlm.nih.gov/pubmed/31718551 http://dx.doi.org/10.1186/s10194-019-1055-3

Ejemplares similares

Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system
por: Eftekhari, S, et al.
Publicado: (2013)

Neuropeptides and the Nodes of Ranvier in Cranial Headaches
por: Edvinsson, Jacob C. A., et al.
Publicado: (2022)

Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain
por: Edvinsson, Jacob CA, et al.
Publicado: (2021)

Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion
por: Edvinsson, Lars, et al.
Publicado: (2020)

Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HT(1) receptors
por: Edvinsson, Jacob C. A., et al.
Publicado: (2022)

Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects
por: Warfvinge, Karin, et al.
Publicado: (2020)

Understanding side-effects of anti-CGRP and anti-CGRP receptor antibodies
por: Haanes, Kristian Agmund, et al.
Publicado: (2020)

The Axonal Cytoskeleton and the Assembly of Nodes of Ranvier
por: Ghosh, Aniket, et al.
Publicado: (2017)

Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex
por: Maddahi, Aida, et al.
Publicado: (2023)

Modulation of inflammatory mediators in the trigeminal ganglion by botulinum neurotoxin type A: an organ culture study
por: Edvinsson, Jacob, et al.
Publicado: (2015)

Axonal Membranes and Their Domains: Assembly and Function of the Axon Initial Segment and Node of Ranvier
por: Nelson, Andrew D., et al.
Publicado: (2017)

Enhanced Endothelin-1 Mediated Vasoconstriction of the Ophthalmic Artery May Exacerbate Retinal Damage after Transient Global Cerebral Ischemia in Rat
por: Blixt, Frank W., et al.
Publicado: (2016)

Reassembly of the axon initial segment and nodes of Ranvier in regenerated axons of the central nervous system
por: Marin, Miguel A., et al.
Publicado: (2017)

Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca(2+) levels in the perfused and non-perfused isolated rat middle cerebral artery
por: Erdling, André, et al.
Publicado: (2017)

βIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG
por: Yang, Yang, et al.
Publicado: (2007)

Expression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex
por: Maddahi, Aida, et al.
Publicado: (2022)

Assembly of CNS Nodes of Ranvier in Myelinated Nerves Is Promoted by the Axon Cytoskeleton
por: Brivio, Veronica, et al.
Publicado: (2017)

Rodent behavior following a dural inflammation model with anti-CGRP migraine medication treatment
por: Reducha, Philip V., et al.
Publicado: (2023)

Dural administration of inflammatory soup or Complete Freund’s Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion
por: Lukács, M., et al.
Publicado: (2015)

An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves
Publicado: (1990)

Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation
por: Gründemann, Jan, et al.
Publicado: (2015)

Node of Ranvier length as a potential regulator of myelinated axon conduction speed
por: Arancibia-Cárcamo, I Lorena, et al.
Publicado: (2017)

Elucidating Axonal Injuries Through Molecular Modelling of Myelin Sheaths and Nodes of Ranvier
por: Saeedimasine, Marzieh, et al.
Publicado: (2021)

CGRP in Primary Headaches
por: Edvinsson, Lars
Publicado: (2001)

βIVΣ1 spectrin stabilizes the nodes of Ranvier and axon initial segments
por: Lacas-Gervais, Sandra, et al.
Publicado: (2004)

Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing
por: Ford, Marc C., et al.
Publicado: (2015)

Experimental inflammation following dural application of complete Freund’s adjuvant or inflammatory soup does not alter brain and trigeminal microvascular passage
por: Lundblad, Cornelia, et al.
Publicado: (2015)

Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level
por: Eftekhari, Sajedeh, et al.
Publicado: (2011)

Ion Channel Clustering at the Axon Initial Segment and Node of Ranvier Evolved Sequentially in Early Chordates
por: Hill, Alexis S., et al.
Publicado: (2008)

Nodes of Ranvier and axon initial segments are ankyrin G–dependent domains that assemble by distinct mechanisms
por: Dzhashiashvili, Yulia, et al.
Publicado: (2007)

Optical Read-out of Neural Activity in Mammalian Peripheral Axons: Calcium Signaling at Nodes of Ranvier
por: Fontaine, Arjun K., et al.
Publicado: (2017)

The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine
por: Warfvinge, Karin, et al.
Publicado: (2020)

MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats
por: Christensen, Simon T., et al.
Publicado: (2019)

Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function
por: Taylor, Anna M., et al.
Publicado: (2017)

Developmental Changes in Expression of βIV Spectrin Splice Variants at Axon Initial Segments and Nodes of Ranvier
por: Yoshimura, Takeshi, et al.
Publicado: (2017)

Expression of messenger molecules and receptors in rat and human sphenopalatine ganglion indicating therapeutic targets
por: Steinberg, Anna, et al.
Publicado: (2016)

Erratum to: Expression of messenger molecules and receptors in rat and human sphenopalatine ganglion indicating therapeutic targets
por: Steinberg, Anna, et al.
Publicado: (2016)

Comment on “A second trigeminal CGRP receptor: function and expression of the AMY1 receptor”
por: Haanes, Kristian Agmund, et al.
Publicado: (2016)

Calcitonin Gene-Related Peptide (CGRP) in Cerebrovascular Disease
por: Edvinsson, Lars
Publicado: (2002)

Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier
por: Kanda, Hirosato, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8iq7fvspfvd9h6pui51n2i13go