Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis

BACKGROUND: In multiple sclerosis (MS) and in the experimental autoimmune encephalomyelitis (EAE) model of MS, the Nav1.6 voltage-gated sodium (Nav) channel isoform has been implicated as a primary contributor to axonal degeneration. Following demyelination Nav1.6, which is normally co-localized wit...

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Detalles Bibliográficos
Autores principales: Alrashdi, Barakat, Dawod, Bassel, Schampel, Andrea, Tacke, Sabine, Kuerten, Stefanie, Marshall, Jean S., Côté, Patrice D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852902/
https://www.ncbi.nlm.nih.gov/pubmed/31722722
http://dx.doi.org/10.1186/s12974-019-1622-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852902/
https://www.ncbi.nlm.nih.gov/pubmed/31722722
http://dx.doi.org/10.1186/s12974-019-1622-1

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