A Proposal of Conducting Bioequivalence Trials with Gastric pH Modulators for Two Oral Formulations Demonstrating Different Dissolution Profiles at Elevated pH

In this paper, a special case for bioequivalence evaluation of oral formulations is discussed. Drug formulations with different forms of active moieties (e.g., free base and salt) may yield different dissolution characteristics and, thus, differ in absorption at elevated gastric pH. However, routine...

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Detalles Bibliográficos
Autores principales: Zhu, Hao, Chen, Xiaomei, Ahmed, Mariam, Wang, Yaning, Liu, Qi, Uppoor, Ramana S., Kuemmel, Colleen, Mehta, Mehul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853150/
https://www.ncbi.nlm.nih.gov/pubmed/31169344
http://dx.doi.org/10.1111/cts.12658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853150/
https://www.ncbi.nlm.nih.gov/pubmed/31169344
http://dx.doi.org/10.1111/cts.12658

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