CYP2B6 Genotype‐Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers

We investigated the effect of efavirenz on the activities of cytochrome P450 (CYP)1A2, CYP2A6, xanthine oxidase (XO), and N‐acetyltransferase 2 (NAT2), using caffeine as a probe. A single 150 mg oral dose of caffeine was administered to healthy volunteers (n = 58) on two separate occasions; with a s...

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Detalles Bibliográficos
Autores principales: Metzger, Ingrid F., Dave, Nimita, Kreutz, Yvonne, Lu, Jessica B.L., Galinsky, Raymond E., Desta, Zeruesenay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853154/
https://www.ncbi.nlm.nih.gov/pubmed/31339646
http://dx.doi.org/10.1111/cts.12671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853154/
https://www.ncbi.nlm.nih.gov/pubmed/31339646
http://dx.doi.org/10.1111/cts.12671

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