Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells

Bile acids (BAs) are recognised as the causative agents of toxicity in drug-induced cholestasis (DIC). Research in isolated mitochondria and HepG2 cells have demonstrated BA-mediated mitochondrial dysfunction as a key mechanism of toxicity in DIC. However, HepG2 cells are of limited suitability for...

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Detalles Bibliográficos
Autores principales: Penman, Sophie L., Sharma, Parveen, Aerts, Hélène, Park, B. Kevin, Weaver, Richard J., Chadwick, Amy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853172/
https://www.ncbi.nlm.nih.gov/pubmed/31288073
http://dx.doi.org/10.1016/j.tiv.2019.104595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853172/
https://www.ncbi.nlm.nih.gov/pubmed/31288073
http://dx.doi.org/10.1016/j.tiv.2019.104595

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