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Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells
Bile acids (BAs) are recognised as the causative agents of toxicity in drug-induced cholestasis (DIC). Research in isolated mitochondria and HepG2 cells have demonstrated BA-mediated mitochondrial dysfunction as a key mechanism of toxicity in DIC. However, HepG2 cells are of limited suitability for...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Pergamon Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853172/ https://www.ncbi.nlm.nih.gov/pubmed/31288073 http://dx.doi.org/10.1016/j.tiv.2019.104595 |