Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies

Maternofoetal physiologically-based pharmacokinetic models integrating multi-compartmental maternal and foetal units were developed using Simbiology® to estimate prenatal drug exposure. Processes governing drug disposition were described using differential equations with key system and drug-specific...

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Detalles Bibliográficos
Autores principales: Atoyebi, Shakir Adeyinka, Rajoli, Rajith K.R., Adejuyigbe, Ebunoluwa, Owen, Andrew, Bolaji, Oluseye, Siccardi, Marco, Olagunju, Adeniyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853277/
https://www.ncbi.nlm.nih.gov/pubmed/31518681
http://dx.doi.org/10.1016/j.ejps.2019.105068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853277/
https://www.ncbi.nlm.nih.gov/pubmed/31518681
http://dx.doi.org/10.1016/j.ejps.2019.105068

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