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UMAP reveals cryptic population structure and phenotype heterogeneity in large genomic cohorts

Human populations feature both discrete and continuous patterns of variation. Current analysis approaches struggle to jointly identify these patterns because of modelling assumptions, mathematical constraints, or numerical challenges. Here we apply uniform manifold approximation and projection (UMAP...

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Detalles Bibliográficos
Autores principales: Diaz-Papkovich, Alex, Anderson-Trocmé, Luke, Ben-Eghan, Chief, Gravel, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853336/
https://www.ncbi.nlm.nih.gov/pubmed/31675358
http://dx.doi.org/10.1371/journal.pgen.1008432