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NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes
Nucleophosmin (NPM1) is frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation, which creates a nuclear export signal, is characterized by cytoplasmic localization and leukemogeni...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853375/ https://www.ncbi.nlm.nih.gov/pubmed/31675375 http://dx.doi.org/10.1371/journal.pgen.1008463 |