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NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes

Nucleophosmin (NPM1) is frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation, which creates a nuclear export signal, is characterized by cytoplasmic localization and leukemogeni...

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Detalles Bibliográficos
Autores principales:	Darracq, Anaïs, Pak, Helen, Bourgoin, Vincent, Zmiri, Farah, Dellaire, Graham, Affar, El Bachir, Milot, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853375/ https://www.ncbi.nlm.nih.gov/pubmed/31675375 http://dx.doi.org/10.1371/journal.pgen.1008463

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