SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma

Whether SOX2 and ACTL6A/TP63 interact with the Hippo‐YAP1 pathway in esophageal squamous cell carcinoma (ESCC) remains unclear. Here, we reveal that SOX2, ACTL6A, and TP63 are co‐amplified and upregulated in ESCC samples. Multiple SOX2 binding peaks in the locus of WWC1, a Hippo‐YAP1 regulator, and...

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Detalles Bibliográficos
Autores principales: Chai, Yuhang, Li, Qihang, Zhao, Hongying, Zhang, Zhiyu, Yu, Xiaodan, Pang, Lijuan, Liu, Zheng, Zhao, Jin, Wang, Lianghai, Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853808/
https://www.ncbi.nlm.nih.gov/pubmed/31560173
http://dx.doi.org/10.1002/cam4.2569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853808/
https://www.ncbi.nlm.nih.gov/pubmed/31560173
http://dx.doi.org/10.1002/cam4.2569

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