Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy

We show here that soluble CD137 (sCD137), the alternately spliced gene product of Tnfsfr9, effectively treats acute type 1 diabetes (T1D) in nonobese diabetic (NOD) mice. sCD137 significantly delayed development of end-stage disease, preserved insulin+ islet beta cells, and prevented progression to...

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Detalles Bibliográficos
Autores principales: Itoh, Arata, Ortiz, Lorenzo, Kachapati, Kritika, Wu, Yuehong, Adams, David, Bednar, Kyle, Mukherjee, Shibabrata, Chougnet, Claire, Mittler, Robert S., Chen, Yi-Guang, Dolan, Laurence, Ridgway, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853870/
https://www.ncbi.nlm.nih.gov/pubmed/31787971
http://dx.doi.org/10.3389/fimmu.2019.02566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853870/
https://www.ncbi.nlm.nih.gov/pubmed/31787971
http://dx.doi.org/10.3389/fimmu.2019.02566

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