Investigation of protein-protein interactions and hot spot region between PD-1 and PD-L1 by fragment molecular orbital method

Inhibitors to interfere protein-protein interactions (PPI) between programmed cell death 1 (PD-1) and programmed death ligand-1 (PD-L1) block evasion of cancers from immune surveillance. Analyzing hot spot residues in PPI is important for small-molecule drug development. In order to find out hot spo...

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Detalles Bibliográficos
Autores principales: Lim, Hocheol, Chun, Jungho, Jin, Xuemei, Kim, Jongwan, Yoon, JeongHyeok, No, Kyoung Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853875/
https://www.ncbi.nlm.nih.gov/pubmed/31723178
http://dx.doi.org/10.1038/s41598-019-53216-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853875/
https://www.ncbi.nlm.nih.gov/pubmed/31723178
http://dx.doi.org/10.1038/s41598-019-53216-z

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