Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers

Molecular determinants governing the evolution of tumor subclones toward phylogenetic branches or fixation remain unknown. Using sequencing data, we model the propagation and selection of clones expressing distinct categories of BRAF mutations to estimate their evolutionary trajectories. We show tha...

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Detalles Bibliográficos
Autores principales: Gopal, Priyanka, Sarihan, Elif Irem, Chie, Eui Kyu, Kuzmishin, Gwendolyn, Doken, Semihcan, Pennell, Nathan A., Raymond, Daniel P., Murthy, Sudish C., Ahmad, Usman, Raja, Siva, Almeida, Francisco, Sethi, Sonali, Gildea, Thomas R., Peacock, Craig D., Adams, Drew J., Abazeed, Mohamed E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853924/
https://www.ncbi.nlm.nih.gov/pubmed/31723142
http://dx.doi.org/10.1038/s41467-019-13161-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853924/
https://www.ncbi.nlm.nih.gov/pubmed/31723142
http://dx.doi.org/10.1038/s41467-019-13161-x

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