Cargando…

Mechanisms of GABA(B) receptor enhancement of extrasynaptic GABA(A) receptor currents in cerebellar granule cells

Many neurons, including cerebellar granule cells, exhibit a tonic GABA current mediated by extrasynaptic GABA(A) receptors. This current is a critical regulator of firing and the target of many clinically relevant compounds. Using a combination of patch clamp electrophysiology and photolytic uncagin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khatri, Shailesh N., Wu, Wan-Chen, Yang, Ying, Pugh, Jason R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853962/ https://www.ncbi.nlm.nih.gov/pubmed/31723152 http://dx.doi.org/10.1038/s41598-019-53087-4

Ejemplares similares

A Reinforcing Circuit Action of Extrasynaptic GABA(A) Receptor Modulators on Cerebellar Granule Cell Inhibition
por: Santhakumar, Vijayalakshmi, et al.
Publicado: (2013)

Cannabinoid type 2 receptors inhibit GABA(A) receptor-mediated currents in cerebellar Purkinje cells of juvenile mice
por: Sadanandan, Sriity Melley, et al.
Publicado: (2020)

GABA Potency at GABA(A) Receptors Found in Synaptic and Extrasynaptic Zones
por: Mortensen, Martin, et al.
Publicado: (2012)

Metabotropic regulation of extrasynaptic GABA(A) receptors
por: Connelly, William M., et al.
Publicado: (2013)

Mechanisms of inhibition and activation of extrasynaptic αβ GABA(A) receptors
por: Kasaragod, Vikram Babu, et al.
Publicado: (2022)

Extrasynaptic δ‐GABA(A) receptors are high‐affinity muscimol receptors
por: Benkherouf, Ali Y., et al.
Publicado: (2019)

Publisher Correction: Mechanisms of inhibition and activation of extrasynaptic αβ GABA(A) receptors
por: Kasaragod, Vikram Babu, et al.
Publicado: (2022)

Extrasynaptic GABA(A) Receptors and Tonic Inhibition in Rat Auditory Thalamus
por: Richardson, Ben D., et al.
Publicado: (2011)

γ-Hydroxybutyric Acid (GHB) Is Not an Agonist of Extrasynaptic GABA(A) Receptors
por: Connelly, William M., et al.
Publicado: (2013)

Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABA(A) receptors
por: Sun, Yajie, et al.
Publicado: (2013)

Distinct roles of synaptic and extrasynaptic GABA(A)receptors in striatal inhibition dynamics
por: Luo, Ruixi, et al.
Publicado: (2013)

Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors
por: Errington, Adam C., et al.
Publicado: (2011)

Extrasynaptic GABA(A) receptors in mediodorsal thalamic nucleus modulate fear extinction learning
por: Paydar, Afshin, et al.
Publicado: (2014)

Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABA(A) receptors
por: Adams, Joanna M., et al.
Publicado: (2015)

Suppression of Harmaline Tremor by Activation of an Extrasynaptic GABA(A) Receptor: Implications for Essential Tremor
por: Handforth, Adrian, et al.
Publicado: (2018)

The role of spinal cord extrasynaptic α(5)GABA(A) receptors in chronic pain
por: Delgado‐Lezama, Rodolfo, et al.
Publicado: (2021)

Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABA(A) receptors on dendritic spines
por: Afroz, Sonia, et al.
Publicado: (2016)

Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA(A) receptors
por: Falk-Petersen, Christina Birkedahl, et al.
Publicado: (2020)

Abnormal Expression of Synaptic and Extrasynaptic GABA(A) Receptor Subunits in the Dystrophin-Deficient mdx Mouse
por: Zarrouki, Faouzi, et al.
Publicado: (2022)

Increased Sensitivity of Mice Lacking Extrasynaptic δ-Containing GABA(A) Receptors to Histamine Receptor 3 Antagonists
por: Abdurakhmanova, Shamsiiat, et al.
Publicado: (2020)

Fast detection of extrasynaptic GABA with a whole-cell sniffer
por: Christensen, Rasmus K., et al.
Publicado: (2014)

Single Ethanol Withdrawal Regulates Extrasynaptic δ-GABA(A) Receptors Via PKCδ Activation
por: Chen, Juan, et al.
Publicado: (2018)

Activation of Glycine and Extrasynaptic GABA(A) Receptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis
por: Nguyen, Thi Thanh Hoang, et al.
Publicado: (2013)

Extrasynaptic α(6) Subunit-Containing GABA(A) Receptors Modulate Excitability in Turtle Spinal Motoneurons
por: Andres, Carmen, et al.
Publicado: (2014)

Temporal Regulation of GABA(A) Receptor Subunit Expression: Role in Synaptic and Extrasynaptic Communication in the Suprachiasmatic Nucleus
por: Walton, James C., et al.
Publicado: (2017)

GABA and the GABA(A) Receptor
por: Mihic, S. John, et al.
Publicado: (1997)

GABA(B) receptor attenuation of GABA(A) currents in neurons of the mammalian central nervous system
por: Shen, Wen, et al.
Publicado: (2017)

Conditioned Aversion and Neuroplasticity Induced by a Superagonist of Extrasynaptic GABA(A) Receptors: Correlation With Activation of the Oval BNST Neurons and CRF Mechanisms
por: de Miguel, Elena, et al.
Publicado: (2019)

The GABA receptors /
Publicado: (2007)

A Gut Feeling about GABA: Focus on GABA(B) Receptors
por: Hyland, Niall P., et al.
Publicado: (2010)

Exposure to 50 Hz magnetic field modulates GABA(A) currents in cerebellar granule neurons through an EP receptor-mediated PKC pathway
por: Yang, Guang, et al.
Publicado: (2015)

Molecular mechanisms of metabotropic GABA(B) receptor function
por: Shaye, Hamidreza, et al.
Publicado: (2021)

New GABA amides activating GABA(A)-receptors
por: Raster, Peter, et al.
Publicado: (2013)

Autoimmune encephalitis with GABA(B) antibodies, thymoma, and GABA(B) receptor thymic expression
por: Alexopoulos, Harry, et al.
Publicado: (2014)

Ligand-guided homology modelling of the GABA(B2) subunit of the GABA(B) receptor
por: Freyd, Thibaud, et al.
Publicado: (2017)

Inhibition of Nigrostriatal Dopamine Release by Striatal GABA(A) and GABA(B) Receptors
por: Lopes, Emanuel F., et al.
Publicado: (2019)

Structures of metabotropic GABA(B) receptor
por: Papasergi-Scott, Makaía M., et al.
Publicado: (2020)

Modulation of extrasynaptic GABA(A) alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner
por: Donegan, J. J., et al.
Publicado: (2019)

Diversity of structure and function of GABA(B) receptors: a complexity of GABA(B)-mediated signaling
por: TERUNUMA, Miho
Publicado: (2018)

Structural mechanism of ligand activation in human GABA(B) receptor
por: Geng, Yong, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_t46d3i6mtdom2o5phcgmnqd1et