Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality

Endowing chimeric antigen receptor (CAR) T cells with additional potent functionalities holds strong potential for improving their antitumor activity. However, because potency could be deleterious without control, these additional features need to be tightly regulated. Immune pathways offer a wide a...

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Detalles Bibliográficos
Autores principales: Sachdeva, Mohit, Busser, Brian W., Temburni, Sonal, Jahangiri, Billal, Gautron, Anne-Sophie, Maréchal, Alan, Juillerat, Alexandre, Williams, Alan, Depil, Stéphane, Duchateau, Philippe, Poirot, Laurent, Valton, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853973/
https://www.ncbi.nlm.nih.gov/pubmed/31723132
http://dx.doi.org/10.1038/s41467-019-13088-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853973/
https://www.ncbi.nlm.nih.gov/pubmed/31723132
http://dx.doi.org/10.1038/s41467-019-13088-3

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