Ligand induced dissociation of the AR homodimer precedes AR monomer translocation to the nucleus

The androgen receptor (AR) regulates male sexual development. We have now investigated AR homodimerization, hormone-dependent monomerization and nuclear translocation in PC-3 and COS-1 cells, by utilizing mutations associated with the androgen insensitivity syndrome: Pro767Ala, Phe765Leu, Met743Val...

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Detalles Bibliográficos
Autores principales: Shizu, Ryota, Yokobori, Kosuke, Perera, Lalith, Pedersen, Lee, Negishi, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853983/
https://www.ncbi.nlm.nih.gov/pubmed/31723170
http://dx.doi.org/10.1038/s41598-019-53139-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853983/
https://www.ncbi.nlm.nih.gov/pubmed/31723170
http://dx.doi.org/10.1038/s41598-019-53139-9

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