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In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs

Background: High-dose, pharmacological ascorbate (P-AscH(−)) is preferentially cytotoxic to human cancer cells in vitro. Investigations on the efficacy of P-AscH(−) as an adjuvant treatment for multiple human cancers are on-going, but has yet to be formally investigated in dogs. The primary objectiv...

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Detalles Bibliográficos
Autores principales: Musser, Margaret L., Mahaffey, Alyssa L., Fath, Melissa A., Buettner, Garry R., Wagner, Brett A., Schneider, Benjamin K., Seo, Yeon-Jung, Mochel, Jonathan P., Johannes, Chad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854015/
https://www.ncbi.nlm.nih.gov/pubmed/31788483
http://dx.doi.org/10.3389/fvets.2019.00385