A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics

Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever. The bacteria have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive...

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Detalles Bibliográficos
Autores principales: Ahyong, Vida, Berdan, Charles A., Burke, Thomas P., Nomura, Daniel K., Welch, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854040/
https://www.ncbi.nlm.nih.gov/pubmed/31722991
http://dx.doi.org/10.1128/mSphere.00536-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854040/
https://www.ncbi.nlm.nih.gov/pubmed/31722991
http://dx.doi.org/10.1128/mSphere.00536-19

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