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Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients
BACKGROUND: Circulating odd-chain fatty acids pentadecanoic (15:0) and heptadecanoic acid (17:0) are considered to reflect dairy intake. In cohort studies, higher circulating 15:0 and 17:0 were associated with lower type 2 diabetes risk. A recent randomized controlled trial in humans suggested that...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854617/ https://www.ncbi.nlm.nih.gov/pubmed/31754368 http://dx.doi.org/10.1186/s12986-019-0407-y |
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author | Pertiwi, Kamalita Küpers, Leanne K. Wanders, Anne J. de Goede, Janette Zock, Peter L. Geleijnse, Johanna M. |
author_facet | Pertiwi, Kamalita Küpers, Leanne K. Wanders, Anne J. de Goede, Janette Zock, Peter L. Geleijnse, Johanna M. |
author_sort | Pertiwi, Kamalita |
collection | PubMed |
description | BACKGROUND: Circulating odd-chain fatty acids pentadecanoic (15:0) and heptadecanoic acid (17:0) are considered to reflect dairy intake. In cohort studies, higher circulating 15:0 and 17:0 were associated with lower type 2 diabetes risk. A recent randomized controlled trial in humans suggested that fiber intake also increased circulating 15:0 and 17:0, potentially resulting from fermentation by gut microbes. We examined the associations of dairy and fiber intake with circulating 15:0 and 17:0 in patients with a history of myocardial infarction (MI). METHODS: We performed cross-sectional analyses in a subsample of 869 Dutch post-MI patients of the Alpha Omega Cohort who had data on dietary intake and circulating fatty acids. Dietary intakes (g/d) were assessed using a 203-item food frequency questionnaire. Circulating 15:0 and 17:0 (as % of total fatty acids) were measured in plasma phospholipids (PL) and cholesteryl esters (CE). Spearman correlations (r(s)) were computed between intakes of total dairy, dairy fat, fiber, and circulating 15:0 and 17:0. RESULTS: Patients were on average 69 years old, 78% was male and 21% had diabetes. Total dairy intake comprised predominantly milk and yogurt (69%). Dairy fat was mainly derived from cheese (47%) and milk (15%), and fiber was mainly from grains (43%). Circulating 15:0 in PL was significantly correlated with total dairy and dairy fat intake (both r(s) = 0.19, p < 0.001), but not with dietary fiber intake (r(s) = 0.05, p = 0.11). Circulating 17:0 in PL was correlated both with dairy intake (r(s) = 0.14 for total dairy and 0.11 for dairy fat, p < 0.001), and fiber intake (r(s) = 0.19, p < 0.001). Results in CE were roughly similar, except for a weaker correlation of CE 17:0 with fiber (r(s) = 0.11, p = 0.001). Circulating 15:0 was highest in those with high dairy intake irrespective of fiber intake, while circulating 17:0 was highest in those with high dairy and fiber intake. CONCLUSIONS: In our cohort of post-MI patients, circulating 15:0 was associated with dairy intake but not fiber intake, whereas circulating 17:0 was associated with both dairy and fiber intake. These data suggest that cardiometabolic health benefits previously attributed to 17:0 as a biomarker of dairy intake may partly be explained by fiber intake. |
format | Online Article Text |
id | pubmed-6854617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68546172019-11-21 Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients Pertiwi, Kamalita Küpers, Leanne K. Wanders, Anne J. de Goede, Janette Zock, Peter L. Geleijnse, Johanna M. Nutr Metab (Lond) Research BACKGROUND: Circulating odd-chain fatty acids pentadecanoic (15:0) and heptadecanoic acid (17:0) are considered to reflect dairy intake. In cohort studies, higher circulating 15:0 and 17:0 were associated with lower type 2 diabetes risk. A recent randomized controlled trial in humans suggested that fiber intake also increased circulating 15:0 and 17:0, potentially resulting from fermentation by gut microbes. We examined the associations of dairy and fiber intake with circulating 15:0 and 17:0 in patients with a history of myocardial infarction (MI). METHODS: We performed cross-sectional analyses in a subsample of 869 Dutch post-MI patients of the Alpha Omega Cohort who had data on dietary intake and circulating fatty acids. Dietary intakes (g/d) were assessed using a 203-item food frequency questionnaire. Circulating 15:0 and 17:0 (as % of total fatty acids) were measured in plasma phospholipids (PL) and cholesteryl esters (CE). Spearman correlations (r(s)) were computed between intakes of total dairy, dairy fat, fiber, and circulating 15:0 and 17:0. RESULTS: Patients were on average 69 years old, 78% was male and 21% had diabetes. Total dairy intake comprised predominantly milk and yogurt (69%). Dairy fat was mainly derived from cheese (47%) and milk (15%), and fiber was mainly from grains (43%). Circulating 15:0 in PL was significantly correlated with total dairy and dairy fat intake (both r(s) = 0.19, p < 0.001), but not with dietary fiber intake (r(s) = 0.05, p = 0.11). Circulating 17:0 in PL was correlated both with dairy intake (r(s) = 0.14 for total dairy and 0.11 for dairy fat, p < 0.001), and fiber intake (r(s) = 0.19, p < 0.001). Results in CE were roughly similar, except for a weaker correlation of CE 17:0 with fiber (r(s) = 0.11, p = 0.001). Circulating 15:0 was highest in those with high dairy intake irrespective of fiber intake, while circulating 17:0 was highest in those with high dairy and fiber intake. CONCLUSIONS: In our cohort of post-MI patients, circulating 15:0 was associated with dairy intake but not fiber intake, whereas circulating 17:0 was associated with both dairy and fiber intake. These data suggest that cardiometabolic health benefits previously attributed to 17:0 as a biomarker of dairy intake may partly be explained by fiber intake. BioMed Central 2019-11-13 /pmc/articles/PMC6854617/ /pubmed/31754368 http://dx.doi.org/10.1186/s12986-019-0407-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Pertiwi, Kamalita Küpers, Leanne K. Wanders, Anne J. de Goede, Janette Zock, Peter L. Geleijnse, Johanna M. Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients |
title | Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients |
title_full | Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients |
title_fullStr | Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients |
title_full_unstemmed | Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients |
title_short | Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients |
title_sort | associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854617/ https://www.ncbi.nlm.nih.gov/pubmed/31754368 http://dx.doi.org/10.1186/s12986-019-0407-y |
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