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Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients

BACKGROUND: Circulating odd-chain fatty acids pentadecanoic (15:0) and heptadecanoic acid (17:0) are considered to reflect dairy intake. In cohort studies, higher circulating 15:0 and 17:0 were associated with lower type 2 diabetes risk. A recent randomized controlled trial in humans suggested that...

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Autores principales: Pertiwi, Kamalita, Küpers, Leanne K., Wanders, Anne J., de Goede, Janette, Zock, Peter L., Geleijnse, Johanna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854617/
https://www.ncbi.nlm.nih.gov/pubmed/31754368
http://dx.doi.org/10.1186/s12986-019-0407-y
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author Pertiwi, Kamalita
Küpers, Leanne K.
Wanders, Anne J.
de Goede, Janette
Zock, Peter L.
Geleijnse, Johanna M.
author_facet Pertiwi, Kamalita
Küpers, Leanne K.
Wanders, Anne J.
de Goede, Janette
Zock, Peter L.
Geleijnse, Johanna M.
author_sort Pertiwi, Kamalita
collection PubMed
description BACKGROUND: Circulating odd-chain fatty acids pentadecanoic (15:0) and heptadecanoic acid (17:0) are considered to reflect dairy intake. In cohort studies, higher circulating 15:0 and 17:0 were associated with lower type 2 diabetes risk. A recent randomized controlled trial in humans suggested that fiber intake also increased circulating 15:0 and 17:0, potentially resulting from fermentation by gut microbes. We examined the associations of dairy and fiber intake with circulating 15:0 and 17:0 in patients with a history of myocardial infarction (MI). METHODS: We performed cross-sectional analyses in a subsample of 869 Dutch post-MI patients of the Alpha Omega Cohort who had data on dietary intake and circulating fatty acids. Dietary intakes (g/d) were assessed using a 203-item food frequency questionnaire. Circulating 15:0 and 17:0 (as % of total fatty acids) were measured in plasma phospholipids (PL) and cholesteryl esters (CE). Spearman correlations (r(s)) were computed between intakes of total dairy, dairy fat, fiber, and circulating 15:0 and 17:0. RESULTS: Patients were on average 69 years old, 78% was male and 21% had diabetes. Total dairy intake comprised predominantly milk and yogurt (69%). Dairy fat was mainly derived from cheese (47%) and milk (15%), and fiber was mainly from grains (43%). Circulating 15:0 in PL was significantly correlated with total dairy and dairy fat intake (both r(s) = 0.19, p < 0.001), but not with dietary fiber intake (r(s) = 0.05, p = 0.11). Circulating 17:0 in PL was correlated both with dairy intake (r(s) = 0.14 for total dairy and 0.11 for dairy fat, p < 0.001), and fiber intake (r(s) = 0.19, p < 0.001). Results in CE were roughly similar, except for a weaker correlation of CE 17:0 with fiber (r(s) = 0.11, p = 0.001). Circulating 15:0 was highest in those with high dairy intake irrespective of fiber intake, while circulating 17:0 was highest in those with high dairy and fiber intake. CONCLUSIONS: In our cohort of post-MI patients, circulating 15:0 was associated with dairy intake but not fiber intake, whereas circulating 17:0 was associated with both dairy and fiber intake. These data suggest that cardiometabolic health benefits previously attributed to 17:0 as a biomarker of dairy intake may partly be explained by fiber intake.
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spelling pubmed-68546172019-11-21 Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients Pertiwi, Kamalita Küpers, Leanne K. Wanders, Anne J. de Goede, Janette Zock, Peter L. Geleijnse, Johanna M. Nutr Metab (Lond) Research BACKGROUND: Circulating odd-chain fatty acids pentadecanoic (15:0) and heptadecanoic acid (17:0) are considered to reflect dairy intake. In cohort studies, higher circulating 15:0 and 17:0 were associated with lower type 2 diabetes risk. A recent randomized controlled trial in humans suggested that fiber intake also increased circulating 15:0 and 17:0, potentially resulting from fermentation by gut microbes. We examined the associations of dairy and fiber intake with circulating 15:0 and 17:0 in patients with a history of myocardial infarction (MI). METHODS: We performed cross-sectional analyses in a subsample of 869 Dutch post-MI patients of the Alpha Omega Cohort who had data on dietary intake and circulating fatty acids. Dietary intakes (g/d) were assessed using a 203-item food frequency questionnaire. Circulating 15:0 and 17:0 (as % of total fatty acids) were measured in plasma phospholipids (PL) and cholesteryl esters (CE). Spearman correlations (r(s)) were computed between intakes of total dairy, dairy fat, fiber, and circulating 15:0 and 17:0. RESULTS: Patients were on average 69 years old, 78% was male and 21% had diabetes. Total dairy intake comprised predominantly milk and yogurt (69%). Dairy fat was mainly derived from cheese (47%) and milk (15%), and fiber was mainly from grains (43%). Circulating 15:0 in PL was significantly correlated with total dairy and dairy fat intake (both r(s) = 0.19, p < 0.001), but not with dietary fiber intake (r(s) = 0.05, p = 0.11). Circulating 17:0 in PL was correlated both with dairy intake (r(s) = 0.14 for total dairy and 0.11 for dairy fat, p < 0.001), and fiber intake (r(s) = 0.19, p < 0.001). Results in CE were roughly similar, except for a weaker correlation of CE 17:0 with fiber (r(s) = 0.11, p = 0.001). Circulating 15:0 was highest in those with high dairy intake irrespective of fiber intake, while circulating 17:0 was highest in those with high dairy and fiber intake. CONCLUSIONS: In our cohort of post-MI patients, circulating 15:0 was associated with dairy intake but not fiber intake, whereas circulating 17:0 was associated with both dairy and fiber intake. These data suggest that cardiometabolic health benefits previously attributed to 17:0 as a biomarker of dairy intake may partly be explained by fiber intake. BioMed Central 2019-11-13 /pmc/articles/PMC6854617/ /pubmed/31754368 http://dx.doi.org/10.1186/s12986-019-0407-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Pertiwi, Kamalita
Küpers, Leanne K.
Wanders, Anne J.
de Goede, Janette
Zock, Peter L.
Geleijnse, Johanna M.
Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients
title Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients
title_full Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients
title_fullStr Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients
title_full_unstemmed Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients
title_short Associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients
title_sort associations of dairy and fiber intake with circulating odd-chain fatty acids in post-myocardial infarction patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854617/
https://www.ncbi.nlm.nih.gov/pubmed/31754368
http://dx.doi.org/10.1186/s12986-019-0407-y
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