Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

BACKGROUND: Temozolomide (TMZ) is the most commonly used chemotherapeutic agent used to treat glioblastoma (GBM), which causes significant DNA damage to highly proliferative cells. Our observations have added to accumulating evidence that TMZ induces stress-responsive cellular programs known to prom...

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Detalles Bibliográficos
Autores principales: Harder, Bryan G., Peng, Sen, Sereduk, Christopher P., Sodoma, Andrej M., Kitange, Gaspar J., Loftus, Joseph C., Sarkaria, Jann N., Tran, Nhan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854621/
https://www.ncbi.nlm.nih.gov/pubmed/31726966
http://dx.doi.org/10.1186/s10020-019-0116-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854621/
https://www.ncbi.nlm.nih.gov/pubmed/31726966
http://dx.doi.org/10.1186/s10020-019-0116-z

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