Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture

BACKGROUND: Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint inflammation and, thereby, cartilage degeneration. In the case of interleukin-1 (IL-1) inhibition using its receptor antagonist (IL-1...

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Detalles Bibliográficos
Autores principales: Mehta, Shikhar, Akhtar, Sumayyah, Porter, Ryan M., Önnerfjord, Patrik, Bajpayee, Ambika G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854651/
https://www.ncbi.nlm.nih.gov/pubmed/31722745
http://dx.doi.org/10.1186/s13075-019-2003-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854651/
https://www.ncbi.nlm.nih.gov/pubmed/31722745
http://dx.doi.org/10.1186/s13075-019-2003-y

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