N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into fibrils. However, it remains unclear if LGMN-cleaved Tau fragments accumulate in AD Tau inc...

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Detalles Bibliográficos
Autores principales: Schlegel, Kerstin, Awwad, Khader, Heym, Roland G., Holzinger, David, Doell, Annika, Barghorn, Stefan, Jahn, Thomas R., Klein, Corinna, Mordashova, Yulia, Schulz, Michael, Gasparini, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854719/
https://www.ncbi.nlm.nih.gov/pubmed/31722749
http://dx.doi.org/10.1186/s40478-019-0831-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854719/
https://www.ncbi.nlm.nih.gov/pubmed/31722749
http://dx.doi.org/10.1186/s40478-019-0831-2

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