Cargando…

N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into fibrils. However, it remains unclear if LGMN-cleaved Tau fragments accumulate in AD Tau inc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schlegel, Kerstin, Awwad, Khader, Heym, Roland G., Holzinger, David, Doell, Annika, Barghorn, Stefan, Jahn, Thomas R., Klein, Corinna, Mordashova, Yulia, Schulz, Michael, Gasparini, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854719/ https://www.ncbi.nlm.nih.gov/pubmed/31722749 http://dx.doi.org/10.1186/s40478-019-0831-2

Ejemplares similares

Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain
por: Frey, Bryan, et al.
Publicado: (2023)

Effects of Resveratrol and Morin on Insoluble Tau in Tau Transgenic Mice
por: Yu, Kwun Chung, et al.
Publicado: (2018)

Anti-tau antibody reduces insoluble tau and decreases brain atrophy
por: Yanamandra, Kiran, et al.
Publicado: (2015)

CSF tau368/total-tau ratio reflects cognitive performance and neocortical tau better compared to p-tau181 and p-tau217 in cognitively impaired individuals
por: Simrén, Joel, et al.
Publicado: (2022)

Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers
por: Cowan, Catherine M., et al.
Publicado: (2015)

CHIP-mediated hyperubiquitylation of tau promotes its self-assembly into the insoluble tau filaments
por: Kim, Ji Hyeon, et al.
Publicado: (2021)

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy
por: Congdon, Erin E., et al.
Publicado: (2016)

A driver or a passenger? D421-caspase cleaved tau is associated with aggregated and insoluble tau
por: Gibson, Yolanda, et al.
Publicado: (2013)

Tau passive immunization inhibits not only tau but also Aβ pathology
por: Dai, Chun-ling, et al.
Publicado: (2017)

Presence of insoluble Tau following rotenone exposure ameliorates basic pathways associated with neurodegeneration
por: Chaves, Rodrigo S., et al.
Publicado: (2016)

An immuno-enrichment free, validated quantification of tau protein in human CSF by LC-MS/MS
por: Self, Wade, et al.
Publicado: (2022)

Run 368 P
por: Colchester, R J
Publicado: (1973)

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau
por: Taniguchi-Watanabe, Sayuri, et al.
Publicado: (2015)

Updated Measurement of the \tau Polarisation in \tau -> \tau(K)\nu_\tau
por: Moraes, D, et al.
Publicado: (1998)

Nuclear Legumain Activity in Colorectal Cancer
por: Haugen, Mads H., et al.
Publicado: (2013)

Prognostic value of legumain in uveal melanoma
por: WU, TONG, et al.
Publicado: (2016)

Legumain Promotes Atherosclerotic Vascular Remodeling
por: Ozawa, Nana, et al.
Publicado: (2019)

Search for the decays $B_s^0\to\tau^+\tau^-$ and $B^0\to\tau^+\tau^-$
por: Aaij, Roel, et al.
Publicado: (2017)

Measurement of sigma_tau+ tau- and A^tau+ tau- _FB with '92 data
por: Ganis, G, et al.
Publicado: (1994)

$Z \to \tau\tau$ and $W \to \tau\nu_\tau$ Cross-Sections at the LHC
por: Ilten, Philip
Publicado: (2012)

Identification of tagging jets in VBF H$\to \tau^{−}\tau^{+}$ process with CMS experiment on Large Hadron Collider at large amount of additionally imposed $pp$-interactions
por: Sirunyan, A M, et al.
Publicado: (2016)

Tau at CMS (From Tau Lepton and Tau in SM measurements to Tau Role in Discovery)
por: Mohammadi, Abdollah
Publicado: (2012)

Higgs to tau tau (MSSM)
por: CMS Collaboration
Publicado: (2013)

Higgs to tau tau at the LHC
por: Farrington, SM
Publicado: (2013)

Search for Higgs boson pairs decaying to WWWW, WW$\tau\tau$, and $\tau\tau\tau\tau$ in proton-proton collisions at $\sqrt{s} = $ 13 TeV
por: Tumasyan, Armen, et al.
Publicado: (2022)

Measurement of the tau polarization in Z$^{0}$ --> $\tau^{+}\tau^{-}$ decay
por: Gómez-Cadenas, J J
Publicado: (1992)

$H\to \tau^{+}\tau^{-}$ and $H^{\pm} \to \tau^{\pm}\nu_{\tau}$ with the ATLAS detector at the LHC
por: Gonçalo, R
Publicado: (2010)

Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates
por: Limorenko, Galina, et al.
Publicado: (2023)

Correction: Nuclear Legumain Activity in Colorectal Cancer
por: Haugen, Mads H., et al.
Publicado: (2013)

The Mammalian Cysteine Protease Legumain in Health and Disease
por: Solberg, Rigmor, et al.
Publicado: (2022)

Library of anomalous $\tau\tau\gamma$ couplings for $\tau^{+} \tau^{-} (n \gamma)$ Monte Carlo programs
por: Paul, Thomas Cantzon, et al.
Publicado: (1999)

Preliminary results on sigma_tau+ tau- and A^tau+ tau-_FB with '93 data (For Summer Conferences)
por: Ganis, G, et al.
Publicado: (1994)

The $\tau$-polarisation test for the $H/A \to \tau^{+}\tau^{-}$ signal at the LHC
por: Moretti, S., et al.
Publicado: (2002)

Correlation measurements in $Z \rightarrow \tau^{+}\tau^{-}$ and the $\tau$ neutrino helicity
por: Buskulic, Damir, et al.
Publicado: (1993)

Study of H -> Tau Tau with Hadronic Tau Decays in CMS
por: Kinnunen, Ritva, et al.
Publicado: (2003)

$Z \to \tau \tau$ and $W \to \tau \nu$ Cross-Sections at LHC
por: Ilten, P
Publicado: (2012)

Determination of the structure of $\tau$ decays in the reaction e+e- --> $\tau^{+}\tau^{-}$ --> $\varrho^{+}\overline{\nu}_{\tau}\varrho$ $^{-}\nu_{\tau}$ and a precision measurement of the $\tau$-neutrino helicity
por: Albrecht, H, et al.
Publicado: (1994)

Measurement of $\tau$ production and decay parameters with the process $e^{+}e^{-} \to Z^{0} \to \tau^{+}\tau^{-} \tau \to $\mu\nu_{\tau}\nu_{\mu}$
por: Roehn, S
Publicado: (1991)

On the Lorentz Structure of Z --> tau tau
por: Stiegler, U
Publicado: (1992)

Tau physics and tau-charm factories
por: Pich, Antonio
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_3kpmcjf2ean34spoo7b1g3vett