Cargando…

m(6)A modification suppresses ocular melanoma through modulating HINT2 mRNA translation

BACKGROUND: Dynamic N(6)-methyladenosine (m(6)A) RNA modification generated and erased by N(6)-methyltransferases and demethylases regulates gene expression, alternative splicing and cell fate. Ocular melanoma, comprising uveal melanoma (UM) and conjunctival melanoma (CM), is the most common primary...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jia, Ruobing, Chai, Peiwei, Wang, Shanzheng, Sun, Baofa, Xu, Yangfan, Yang, Ying, Ge, Shengfang, Jia, Renbing, Yang, Yun-Gui, Fan, Xianqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854757/ https://www.ncbi.nlm.nih.gov/pubmed/31722709 http://dx.doi.org/10.1186/s12943-019-1088-x

Ejemplares similares

Histone lactylation drives oncogenesis by facilitating m(6)A reader protein YTHDF2 expression in ocular melanoma
por: Yu, Jie, et al.
Publicado: (2021)

Targeting histone deacetylase suppresses tumor growth through eliciting METTL14‐modified m(6)A RNA methylation in ocular melanoma
por: Zhuang, Ai, et al.
Publicado: (2023)

An Artificial CTCF Peptide Triggers Efficient Therapeutic Efficacy in Ocular Melanoma
por: Wen, Xuyang, et al.
Publicado: (2020)

Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation
por: Shi, Hanhan, et al.
Publicado: (2020)

SKP2 targeted inhibition suppresses human uveal melanoma progression by blocking ubiquitylation of p27
por: Zhao, Hongbo, et al.
Publicado: (2019)

Novel insights on m(6)A RNA methylation in tumorigenesis: a double-edged sword
por: Wang, Shaoyun, et al.
Publicado: (2018)

Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis
por: Chai, Peiwei, et al.
Publicado: (2020)

Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma
por: Zhuang, Ai, et al.
Publicado: (2022)

Epigenetic drug library screening reveals targeting DOT1L abrogates NAD(+) synthesis by reprogramming H3K79 methylation in uveal melanoma
por: Gu, Xiang, et al.
Publicado: (2023)

Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis
por: Chai, Peiwei, et al.
Publicado: (2020)

Extrachromosomal circular DNA: biogenesis, structure, functions and diseases
por: Yang, Ludi, et al.
Publicado: (2022)

Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities
por: Ge, Tongxin, et al.
Publicado: (2022)

Updates on the clinical diagnosis and management of ocular sebaceous carcinoma: a brief review of the literature
por: Xu, Yangfan, et al.
Publicado: (2018)

Early Reconstruction Surgery Resolving Visual Occlusion and Ocular Malformation: A Case Report
por: Xu, Shiqiong, et al.
Publicado: (2014)

Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis
por: Chai, Peiwei, et al.
Publicado: (2018)

Uveal melanoma: progress in molecular biology and therapeutics
por: Li, Yongyun, et al.
Publicado: (2020)

NSUN2‐mediated m(5)C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression
por: Zuo, Sipeng, et al.
Publicado: (2023)

Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis
por: Yu, Jie, et al.
Publicado: (2023)

Novel insights into chromosomal conformations in cancer
por: Jia, Ruobing, et al.
Publicado: (2017)

Long Non-coding RNA LINC-PINT Suppresses Cell Proliferation and Migration of Melanoma via Recruiting EZH2
por: Xu, Yangfan, et al.
Publicado: (2019)

BMP9 promotes cutaneous wound healing by activating Smad1/5 signaling pathways and cytoskeleton remodeling
por: Chai, Peiwei, et al.
Publicado: (2021)

Novel insights into histone lysine methyltransferases in cancer therapy: From epigenetic regulation to selective drugs
por: Liao, Qili, et al.
Publicado: (2023)

LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3Kγ promoter
por: Ni, Hongyan, et al.
Publicado: (2020)

Role of Epigenetics in Uveal Melanoma
por: Li, Yongyun, et al.
Publicado: (2017)

Dose‐Dependent Carbon‐Dot‐Induced ROS Promote Uveal Melanoma Cell Tumorigenicity via Activation of mTOR Signaling and Glutamine Metabolism
por: Ding, Yi, et al.
Publicado: (2021)

Clinical characteristics and mutation Spectrum of NF1 in 12 Chinese families with orbital/periorbital plexiform Neurofibromatosis type 1
por: Chai, Peiwei, et al.
Publicado: (2019)

Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment
por: Shi, Yingyun, et al.
Publicado: (2017)

Recent Understandings Toward Coronavirus Disease 2019 (COVID-19): From Bench to Bedside
por: Yu, Jie, et al.
Publicado: (2020)

A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3
por: He, Xiaoyu, et al.
Publicado: (2020)

The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword
por: Chai, Peiwei, et al.
Publicado: (2016)

Novel insights into extrachromosomal DNA: redefining the onco-drivers of tumor progression
por: Gu, Xiang, et al.
Publicado: (2020)

CDC20 Knockdown and Acidic Microenvironment Collaboratively Promote Tumorigenesis through Inhibiting Autophagy and Apoptosis
por: Gu, Qingying, et al.
Publicado: (2020)

lncRNA HotairM1 Depletion Promotes Self-Renewal of Cancer Stem Cells through HOXA1-Nanog Regulation Loop
por: Li, Fang, et al.
Publicado: (2020)

Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency
por: Kim, Sun Chang, et al.
Publicado: (2021)

Multi‐omics and case‐control analyses identify immunoglobulin M as a tumour‐derived serum biomarker of ocular adnexal extranodal marginal zone lymphoma
por: Shi, Jiahao, et al.
Publicado: (2023)

Modulation of translational decoding by m(6)A modification of mRNA
por: Jain, Sakshi, et al.
Publicado: (2023)

The Long Non-Coding RNA RHPN1-AS1 Promotes Uveal Melanoma Progression
por: Lu, Linna, et al.
Publicado: (2017)

The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma
por: Zhang, Leilei, et al.
Publicado: (2018)

Control of mRNA translation by dynamic ribosome modification
por: Grenga, Lucia, et al.
Publicado: (2020)

Hierarchical Clustering of Cutaneous Melanoma Based on Immunogenomic Profiling
por: Yu, Jie, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_c2u5jtdv37ju4mthlq81j2br56